Blar i forfatter "Halsør, Marie-Josée Haglund"

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    • Along the path of bacterial nonulosonic acids. A study of the bio- and in vitro synthesis of sialic acid related compounds 

      Halsør, Marie-Josée Haglund (Doctoral thesis; Doktorgradsavhandling, 2019-10-25)
      Nonulosonic acids (NulOs) are sugars expressed on the surface of bacterial cells as well as vertebrates and are involved in a multitude of physiological and pathogenic processes. Their biosynthesis is directed by gene clusters that vary in both gene content and organization, leading to a diverse family of compounds. The exploration of this diversity is relatively recent, helped by the amount of ...

    • The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer 

      Halsør, Marie-Josée Haglund; Rothweiler, Ulli; Altermark, Bjørn; Ræder, Inger Lin Uttakleiv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)
      <i>N</i>-Acetylglucosamine 2-epimerases (AGEs) catalyze the interconversion of <i>N</i>-acetylglucosamine and <i>N</i>-acetylmannosamine. They can be used to perform the first step in the synthesis of sialic acid from <i>N</i>-acetylglucosamine, which makes the need for efficient AGEs a priority. This study presents the structure of the AGE from <i>Nostoc</i> sp. KVJ10 collected in northern Norway, ...

    • Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa 

      Halsør, Marie-Josée Haglund; Altermark, Bjørn; Ræder, Inger Lin Uttakleiv (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-20)
      Nonulosonic acid (NulO) biosynthesis in bacteria is directed by <i>nab</i> gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of <i>Aliivibrio salmonicida</i> and <i>Moritella viscosa</i> strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method ...